Mucosal surfaces are continuously bombarded by and constitute major portals of entry for pathogens, allergens, and pollutants. The breach in physical barriers, imbalance in microbiota, dysfunctional immunity, and coinfections emanate mucosal dysfunction and disease. The immune orchestration by mucosal-lining and hematopoietic cells dictates the outcome of a disease. Using cutting-edge animal models of mucosal diseases, including primary infections, cystic fibrosis, COPD, pulmonary fibrosis, and IBD, complemented by OMICS data, the faculty and students in Mucosal Immunology are involved in studying immunopathogenesis and immunological interventions to develop preventive measures and therapeutics.